Joshua Corbin

Joshua Corbin
Associate Professor of Pediatrics and Pharmacology and Physiology, GW School of Medicine and Health Sciences; Principal Investigator, Center for Neuroscience Research, Children's National Medical Center
[email protected]


Research Focus


Genetic and cellular processes that govern normal development of the amygdala, as well as the underlying defects in these processes that occur during developmental disorders, with a specific focus on autism and autism spectrum disorders.


  • Wired for behaviors: from development to function of innate limbic system circuitry. Sokolowski K, Corbin JG. Front Mol Neurosci. 2012 Apr 26;5:55. doi: 10.3389/fnmol.2012.00055. eCollection 2012. PMID: 22557946
  • Specification of select hypothalamic circuits and innate behaviors by the embryonic patterning gene dbx1. Sokolowski K, Esumi S, Hirata T, Kamal Y, Tran T, Lam A, Oboti L, Brighthaupt SC, Zaghlula M, Martinez J, Ghimbovschi S, Knoblach S, Pierani A, Tamamaki N, Shah NM, Jones KS, Corbin JG. Neuron. 2015 Apr 22;86(2):403-16. doi: 10.1016/j.neuron.2015.03.022. Epub 2015 Apr 9. PMID: 25864637
  • Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei. Sokolowski K, Tran T, Esumi S, Kamal Y, Oboti L, Lischinsky J, Goodrich M, Lam A, Carter M, Nakagawa Y, Corbin JG. Neural Dev. 2016 May 21;11(1):12. doi: 10.1186/s13064-016-0067-9. PMID: 27209204 
  • Homeostatic responses fail to correct defective amygdala inhibitory circuit maturation in fragile X syndrome. Vislay RL, Martin BS, Olmos-Serrano JL, Kratovac S, Nelson DL, Corbin JG, Huntsman MM. J Neurosci. 2013 Apr 24;33(17):7548-58. doi: 10.1523/JNEUROSCI.2764-12.2013. PMID: 23616559 
  • Amygdala regulation of fear and emotionality in fragile X syndrome. Olmos-Serrano JL, Corbin JG. Dev Neurosci. 2011;33(5):365-78. doi: 10.1159/000329424. Epub 2011 Sep 1. Review. PMID: 21893939
  • Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system. Cocas LA, Georgala PA, Mangin JM, Clegg JM, Kessaris N, Haydar TF, Gallo V, Price DJ, Corbin JG. J Neurosci. 2011 Apr 6;31(14):5313-24. doi: 10.1523/JNEUROSCI.3867-10.2011. PMID: 21471366
  • The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome. Olmos-Serrano JL, Corbin JG, Burns MP. Dev Neurosci. 2011;33(5):395-403. doi: 10.1159/000332884. Epub 2011 Nov 8. PMID: 22067669
  • Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. Olmos-Serrano JL, Paluszkiewicz SM, Martin BS, Kaufmann WE, Corbin JG, Huntsman MM. J Neurosci. 2010 Jul 21;30(29):9929-38. doi: 10.1523/JNEUROSCI.1714-10.2010. PMID: 20660275
  • Quantum dots for neuroscience research: new tools for old problems? Corbin JG, Haydar TF. Nanomedicine (Lond). 2007 Oct;2(5):579-81. Review. No abstract available. PMID: 17976020
  • Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system. Carney RS, Alfonso TB, Cohen D, Dai H, Nery S, Stoica B, Slotkin J, Bregman BS, Fishell G, Corbin JG. J Neurosci. 2006 Nov 8;26(45):11562-74. PMID: 17093077
  • Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala. Hirata T, Li P, Lanuza GM, Cocas LA, Huntsman MM, Corbin JG. Nat Neurosci. 2009 Feb;12(2):141-9. doi: 10.1038/nn.2241. Epub 2009 Jan 11. PMID: 19136974
  • A cyclic GMP-stimulated cyclic nucleotide phosphodiesterase gene is highly expressed in the limbic system of the rat brain. Repaske DR, Corbin JG, Conti M, Goy MF. Neuroscience. 1993 Oct;56(3):673-86. PMID: 8305078 
  • Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator. Martin BS, Martinez-Botella G, Loya CM, Salituro FG, Robichaud AJ, Huntsman MM, Ackley MA, Doherty JJ, Corbin JG. J Neurosci Res. 2016 Jun;94(6):568-78. doi: 10.1002/jnr.23632. Epub 2015 Aug 26. PMID: 26308557
  • Programmed cell death is impaired in the developing brain of FMR1 mutants. Cheng Y, Corbin JG, Levy RJ. Dev Neurosci. 2013;35(4):347-58. doi: 10.1159/000353248. Epub 2013 Jul 27. PMID: 23900139
  • Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia. Jones KS, Corbin JG, Huntsman MM. PLoS One. 2014 Oct 7;9(10):e109303. doi: 10.1371/journal.pone.0109303. eCollection 2014. PMID: 25290690
  • Regulation of neural progenitor cell development in the nervous system. Corbin JG, Gaiano N, Juliano SL, Poluch S, Stancik E, Haydar TF. J Neurochem. 2008 Sep;106(6):2272-87. Review. PMID: 18819190
  • Developmental origin of preBötzinger complex respiratory neurons. Gray PA, Hayes JA, Ling GY, Llona I, Tupal S, Picardo MC, Ross SE, Hirata T, Corbin JG, Eugenín J, Del Negro CA. J Neurosci. 2010 Nov 3;30(44):14883-95. doi: 10.1523/JNEUROSCI.4031-10.2010. PMID: 21048147
  • Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala. Cocas LA, Miyoshi G, Carney RS, Sousa VH, Hirata T, Jones KR, Fishell G, Huntsman MM, Corbin JG. J Neurosci. 2009 Dec 16;29(50):15933-46. doi: 10.1523/JNEUROSCI.2525-09.2009. PMID: 20016109
  • The effects of interferon-gamma on the central nervous system. Popko B, Corbin JG, Baerwald KD, Dupree J, Garcia AM. Mol Neurobiol. 1997 Feb-Apr;14(1-2):19-35. Review. PMID: 9170099
  • Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2. Carney RS, Cocas LA, Hirata T, Mansfield K, Corbin JG. Cereb Cortex. 2009 Apr;19(4):745-59. doi: 10.1093/cercor/bhn123. Epub 2008 Aug 12. PMID: 18701439
  • Developmental changes in expression of inhibitory neuronal proteins in the Fragile X Syndrome mouse basolateral amygdala. Kratovac S, Corbin JG. Brain Res. 2013 Nov 6;1537:69-78. doi: 10.1016/j.brainres.2013.08.052. Epub 2013 Sep 2. PMID: 24008143
  • Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala. Carney RS, Mangin JM, Hayes L, Mansfield K, Sousa VH, Fishell G, Machold RP, Ahn S, Gallo V, Corbin JG. Neural Dev. 2010 May 27;5:14. doi: 10.1186/1749-8104-5-14. PMID: 20507551
  • Impaired inhibitory control of cortical synchronization in fragile X syndrome. Paluszkiewicz SM, Olmos-Serrano JL, Corbin JG, Huntsman MM. J Neurophysiol. 2011 Nov;106(5):2264-72. doi: 10.1152/jn.00421.2011. Epub 2011 Jul 27. PMID: 21795626
  • In vivo quantum dot labeling of mammalian stem and progenitor cells. Slotkin JR, Chakrabarti L, Dai HN, Carney RS, Hirata T, Bregman BS, Gallicano GI, Corbin JG, Haydar TF. Dev Dyn. 2007 Dec;236(12):3393-401. PMID: 17626285
  • Developmental mechanisms for the generation of telencephalic interneurons. Corbin JG, Butt SJ. Dev Neurobiol. 2011 Aug;71(8):710-32. doi: 10.1002/dneu.20890. Review. PMID: 21485015
  • The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations. Nery S, Fishell G, Corbin JG. Nat Neurosci. 2002 Dec;5(12):1279-87. PMID: 12411960
  • Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain. Corbin JG, Nery S, Fishell G. Nat Neurosci. 2001 Nov;4 Suppl:1177-82. Review. PMID: 11687827
  • The temporal and spatial origins of cortical interneurons predict their physiological subtype. Butt SJ, Fuccillo M, Nery S, Noctor S, Kriegstein A, Corbin JG, Fishell G. Neuron. 2005 Nov 23;48(4):591-604. PMID: 16301176
  • Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon. Nery S, Corbin JG, Fishell G. Cereb Cortex. 2003 Sep;13(9):895-903. PMID: 12902388
  • Parsing the prosencephalon. Rallu M, Corbin JG, Fishell G. Nat Rev Neurosci. 2002 Dec;3(12):943-51. Review. No abstract available. PMID: 12461551
  • The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. Corbin JG, Gaiano N, Machold RP, Langston A, Fishell G. Development. 2000 Dec;127(23):5007-20. PMID: 11060228
  • Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning. Corbin JG, Rutlin M, Gaiano N, Fishell G. Development. 2003 Oct;130(20):4895-906. Epub 2003 Aug 20. PMID: 12930780
  • Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Machold R, Hayashi S, Rutlin M, Muzumdar MD, Nery S, Corbin JG, Gritli-Linde A, Dellovade T, Porter JA, Rubin LL, Dudek H, McMahon AP, Fishell G. Neuron. 2003 Sep 11;39(6):937-50. Erratum in: Neuron. 2003 Sep 25;40(1):189. PMID: 12971894
  • Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Rallu M, Machold R, Gaiano N, Corbin JG, McMahon AP, Fishell G. Development. 2002 Nov;129(21):4963-74. PMID: 12397105
  • Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala. Martin BS, Corbin JG, Huntsman MM. J Neurophysiol. 2014 Aug 15;112(4):890-902. doi: 10.1152/jn.00597.2013. Epub 2014 May 21. PMID: 24848467
  • Murine Gcm1 gene is expressed in a subset of placental trophoblast cells. Basyuk E, Cross JC, Corbin J, Nakayama H, Hunter P, Nait-Oumesmar B, Lazzarini RA. Dev Dyn. 1999 Apr;214(4):303-11. PMID: 10213386
  • Ectopic expression of Gcm1 induces congenital spinal cord abnormalities. Nait-Oumesmar B, Stecca B, Fatterpekar G, Naidich T, Corbin J, Lazzarini RA. Development. 2002 Aug;129(16):3957-64. PMID: 12135932
  • Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development. Corbin JG, Kelly D, Rath EM, Baerwald KD, Suzuki K, Popko B. Mol Cell Neurosci. 1996 May;7(5):354-70. PMID: 8812062
  • Major histocompatibility complex heavy chain accumulation in the endoplasmic reticulum of oligodendrocytes results in myelin abnormalities. Baerwald KD, Corbin JG, Popko B. J Neurosci Res. 2000 Jan 15;59(2):160-9. PMID: 10650874
  • The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Mao J, McKean DM, Warrier S, Corbin JG, Niswander L, Zohn IE. Development. 2010 Sep;137(18):3079-88. doi: 10.1242/dev.048744. Epub 2010 Aug 11. PMID: 20702562
  • Proximal regions of the olfactory marker protein gene promoter direct olfactory neuron-specific expression in transgenic mice. Walters E, Grillo M, Tarozzo G, Stein-Izsak C, Corbin J, Bocchiaro C, Margolis FL. J Neurosci Res. 1996 Jan 15;43(2):146-60. PMID: 8820963
  • Control of segment-like patterns of gene expression in the mouse cerebellum. Oberdick J, Schilling K, Smeyne RJ, Corbin JG, Bocchiaro C, Morgan JI. Neuron. 1993 Jun;10(6):1007-18. PMID: 8318226 [PubMed - indexed for MEDLINE]
  • Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy. Li P, Fu X, Smith NA, Ziobro J, Curiel J, Tenga MJ, Martin B, Freedman S, Cea-Del Rio CA, Oboti L, Tsuchida TN, Oluigbo C, Yaun A, Magge SN, O'Neill B, Kao A, Zelleke TG, Depositario-Cabacar DT, Ghimbovschi S, Knoblach S, Ho CY, Corbin JG, Goodkin HP, Vicini S, Huntsman MM, Gaillard WD, Valdez G, Liu JS. Neuron. 2017 Oct 11;96(2):387-401.e6. doi: 10.1016/j.neuron.2017.09.044. PMID: 29024662
  • Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues. Lischinsky JE, Sokolowski K, Li P, Esumi S, Kamal Y, Goodrich M, Oboti L, Hammond TR, Krishnamoorthy M, Feldman D, Huntsman M, Liu J, Corbin JG. Elife. 2017 Mar 13;6. pii: e21012. doi: 10.7554/eLife.21012. PMID: 28244870
  • Control of gluconeogenesis in liver. V. Effects of fasting, diabetes, and glucagon on lactate and endogenous metabolism in the perfused rat liver. Exton JH, Corbin JG, Harper SC.J Biol Chem. 1972 Aug 25;247(16):4996-5003. PMID: 5061605
  • Control of gluconeogenesis in liver. IV. Differential effects of fatty acids and glucagon on ketogenesis and gluconeogenesis in the perfused rat liver.Exton JH, Corbin JG, Park CR. J Biol Chem. 1969 Aug 10;244(15):4095-102.